Rs-100235: A high affinity 5-HT4 receptor antagonist
β Scribed by R.D. Clark; A. Jahangir; L.A. Flippin; J.A. Langston; E. Leung; D.W. Bonhaus; E.H.F. Wong; L.G. Johnson; R.M. Eglen
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 205 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0960-894X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
## Abstract magnified image A series of novel ligands for the serotonin 5βHT~2A/C~ receptor subtype bearing the 2βphenylethylamine pharmacophore was synthesized and assayed for its 5βHT~2A~ receptor binding affinity. As the 4β²βarylβsubstituted 2β(2,5βdimethoxyphenyl)ethylamines were previously unk
Hindered rotation analogs of the antipsychotic mazapertine (1) were prepared. These compounds exhibited high affinity for the 5-HTl\* receptor, but not for other serotonin or dopamine receptors. The related p carboline structures were also synthesized and were found to he potent .S-HT~A ligands. 0 1