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Rotenone, Deguelin, Their Metabolites, and the Rat Model of Parkinson's Disease

✍ Scribed by Caboni, Pierluigi; Sherer, Todd B.; Zhang, Nanjing; Taylor, Georgia; Na, Hye Me; Greenamyre, J. Timothy; Casida, John E.

Book ID
115488924
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
244 KB
Volume
17
Category
Article
ISSN
0893-228X

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## Abstract Parkinson's disease (PD) is characterized pathologically by progressive neurodegeneration of the nigrostriatal dopamine (DA) system. Currently, the cause of the disease is unknown, except for a small percentage of familial cases (<10% of total). The rat rotenone model reproduces many of