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Roscovitine Differentially Affects Asynchronously Growing and Synchronized Human MCF-7 Breast Cancer Cells

✍ Scribed by Margarita Maurer; Oxana Komina; Józefa Węsierska-Gądek

Book ID
111399201
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
211 KB
Volume
1171
Category
Article
ISSN
0890-6564

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## Abstract Human MCF‐7 breast cancer cells are relatively resistant to conventional chemotherapy due to the lack of caspase‐3 activity. We reported recently that roscovitine (ROSC), a potent cyclin‐dependent kinase 2 inhibitor, arrests human MCF‐7 breast cancer cells in the G~2~ phase of the cell