## Abstract We reported recently that roscovitine (ROSC), a selective cyclin‐dependent kinase (CDK) inhibitor, arrests human MCF‐7 breast cancer cells in G~2~ phase of the cell cycle, and concomitantly induces apoptosis. Human MCF‐7 breast cancer cells are known to express elevated levels of c‐Ha‐R
Resveratrol modulates roscovitine-mediated cell cycle arrest of human MCF-7 breast cancer cells
✍ Scribed by Józefa Węsierska-Gądek; Matthias P. Kramer; Margarita Maurer
- Book ID
- 116462071
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 572 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0278-6915
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## Abstract The aim of our study was to explore the antiproliferative and pro‐apoptotic action of roscovitine (ROSC) on human breast cancer MCF‐7 cells. We examined the effect of ROSC on cell proliferation, cell cycle progression, nucleolar morphology, posttranslational modifications of histones as
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