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ROS up-regulation mediates Ras-induced changes of cell morphology and motility

✍ Scribed by Antonina Y. Alexandrova; Pavel B. Kopnin; Jury M. Vasiliev; Boris P. Kopnin

Book ID
118204521
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
547 KB
Volume
312
Category
Article
ISSN
0014-4827

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## Abstract Activating Ras mutations are involved in a significant fraction of human tumors. A suppressor screen using a retroviral mouse fibroblast cDNA library was performed to identify novel factors in Ras‐mediated transformation. We identified a novel potent inhibitor of Ras‐mediated morphologi