Glucose-induced up-regulation of CD36 mediates oxidative stress and microvascular endothelial cell dysfunction

Up-regulation of the association between

Up-regulation of the association between heat shock protein 90 and endothelial nitric oxide synthase prevents high glucose-induced apoptosis in human endothelial cells

✍ Lian-Yu Lin; Chien-Yu Lin; Fong-Ming Ho; Chiau S. Liau 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 216 KB 👁 1 views

## Abstract Hyperglycemia is the hallmark of diabetes mellitus. Poor glycemic control is correlated with increased cardiovascular morbidity and mortality. High glucose can trigger endothelial cell apoptosis by de‐activation of endothelial nitric oxide synthase (eNOS). eNOS was recently demonstrated