Room Temperature Palladium Catalyzed Coupling of Acyl Chlorides with Terminal Alkynes.
β Scribed by Russell J. Cox; Dougal J. Ritson; Thomas A. Dane; John Berge; Jonathan P. H. Charmant; Anob Kantacha
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 20 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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π SIMILAR VOLUMES
## Abstract An efficient and mild access to mixed dimethylalkynylaluminum reagents has been developed __via__ a direct Lewis baseβcatalyzed alumination of terminal alkynes by trimethylaluminum. The use of bis(trimethylsilyl)methylamine enables the metalation at room temperature with only 1% of cata
For the first time, conditions have been found for the palladium-catalyzed desulfitative carbon-carbon cross-coupling of arenesulfonyl chlorides with aryl-and alkylacetylenes. Pd 2 (dba) 3 /P(t-Bu) 3 and CuI provide the best catalyst for reactions in refluxing THF and in the presence of K 2 CO 3 .
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