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Palladium-Catalyzed Desulfitative Sonogashira–Hagihara Cross-Couplings of Arenesulfonyl Chlorides and Terminal Alkynes

✍ Scribed by Srinivas Reddy Dubbaka; Pierre Vogel


Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
119 KB
Volume
346
Category
Article
ISSN
1615-4150

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✦ Synopsis


For the first time, conditions have been found for the palladium-catalyzed desulfitative carbon-carbon cross-coupling of arenesulfonyl chlorides with aryl-and alkylacetylenes. Pd 2 (dba) 3 /P(t-Bu) 3 and CuI provide the best catalyst for reactions in refluxing THF and in the presence of K 2 CO 3 .


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