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Roles of threonine 192 and asparagine 382 in agonist and antagonist interactions with M1 muscarinic receptors

โœ Scribed by Xi-Ping Huang; Peter I Nagy; Frederick E Williams; Steven M Peseckis; William S Messer Jr


Book ID
110004061
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
387 KB
Volume
126
Category
Article
ISSN
0007-1188

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The arecoline bioisostere, Lu 25-109-T, displays a pharmacological profile of a partial muscarinic agonist with a several-fold higher affinity for cortical M 1 receptors than for brain stem M 2 receptors and salivary glands M 3 receptors. The compound is selective for muscarinic receptors as it show