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Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance

✍ Scribed by James A. McCubrey; Linda S. Steelman; Steven L. Abrams; John T. Lee; Fumin Chang; Fred E. Bertrand; Patrick M. Navolanic; David M. Terrian; Richard A. Franklin; Antonio B. D’Assoro; Jeffrey L. Salisbury; Maria Clorinda Mazzarino; Franca Stivala; Massimo Libra

Book ID
113418889
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
731 KB
Volume
46
Category
Article
ISSN
0065-2571

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## Abstract Chemotherapy remains a commonly used therapeutic approach for many cancers. Indeed chemotherapy is relatively effective for treatment of certain cancers and it may be the only therapy (besides radiotherapy) that is appropriate for certain cancers. However, a common problem with chemothe