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Roles of mTOR and JNK in serine phosphorylation, translocation, and degradation of IRS-1

✍ Scribed by Kazuyuki Hiratani; Tetsuro Haruta; Akihiro Tani; Junko Kawahara; Isao Usui; Masashi Kobayashi


Book ID
116291081
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
357 KB
Volume
335
Category
Article
ISSN
0006-291X

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Role of mTOR in the degradation of IRS-1
✍ David Hartley; Geoffrey M. Cooper πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 274 KB

## Abstract We have investigated the role of PI 3‐kinase and mTOR in the degradation of IRS‐1 induced by insulin. Inhibition of mTOR with rapamycin resulted in approximately 50% inhibition of the insulin‐induced degradation of IRS‐1. In contrast, inhibition of PI‐3 kinase, an upstream activator of