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Regulation of insulin signalling by hyperinsulinaemia: role of IRS-1/2 serine phosphorylation and the mTOR/p70 S6K pathway

✍ Scribed by M. Ueno; J. B. C. Carvalheira; R. C. Tambascia; R. M. N. Bezerra; M. E. Amaral; E. M. Carneiro; F. Folli; K. G. Franchini; M. J. A. Saad


Publisher
Springer
Year
2005
Tongue
English
Weight
571 KB
Volume
48
Category
Article
ISSN
0012-186X

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✍ Jing Fang; Qiao Meng; Peter K. Vogt; Ruiwen Zhang; Bing-Hua Jiang πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 225 KB

## Abstract Human double minute 2 (HDM2) is an oncoprotein overexpressed in many human cancers. HDM2 expression is regulated at multiple levels in cells. Phosphorylation of HDM2 plays an important role in its post‐translational regulation. In this study, we have shown that the phosphatidylinositol