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Roles of copper accumulation in hepatocarcinogenesis of LEC rats

✍ Scribed by Masaaki Satoh; Norimasa Sawada; Michio Mori

Book ID
101299552
Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
116 KB
Volume
10
Category
Article
ISSN
0896-548X

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✦ Synopsis

The aim of this study was to discover possible mechanisms of hepatocarcinogenesis of the Long-Evans cinnamon (LEC) rat, a new mutant inbred strain that manifests severe jaundice and anemia a few months after birth. The animals have an abnormal accumulation of copper in the liver and a low level of ceruloplasmin in the plasma. The LEC rat may be considered a useful animal model for Wilson's disease and hepatocellular carcinoma. J. Trace Elem.

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✍ Hideko Sone; Mitsuaki Maeda; Masahiro Gotoh; Keiji Wakabayashi; Takao Ono; Michi πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 English βš– 558 KB

## Abstract The concentration of copper in the livers of Long‐Evans rats with cinnamon‐like coat color (LEC), in which hepatitis and then hepatomas develop spontaneously, was recently found to be abnormally high. Therefore, we examined the copper concentrations in the livers of LEC F~1~ backcrosses