Roles of CD4+CD25+ T cells in the development of experimental murine allergic conjunctivitis
β Scribed by Atsuki Fukushima; Tomoko Yamaguchi; Tamaki Sumi; Ken Fukuda; Naoki Kumagai; Teruo Nishida; Masaru Takeuchi; Osamu Taguchi; Hisayuki Ueno
- Book ID
- 106097515
- Publisher
- Springer-Verlag
- Year
- 2006
- Tongue
- English
- Weight
- 493 KB
- Volume
- 245
- Category
- Article
- ISSN
- 0065-6100
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## Abstract To evaluate the __in vivo__ effect of immunosuppressive glucocorticoids on CD4^+^CD25^+^ T regulatory cells, we injected dexamethasone (Dex) into BALB/c mice. Administrationof Dex enhanced the proportion of CD4^+^CD25^+^ cells and the ratio of CD4^+^CD25^+^ cells to CD4^+^CD25^β^ cells
CD4 Ψ CD25 Ψ regulatory T cells (Treg) are important mediators of peripheral immune tolerance; however, whether Treg participate also in hepatic immune tolerance is not clear. Therefore, we tested the potential of Treg to suppress stimulation of CD4 Ψ T cells by liver sinusoidal endothelial cells (L