Breast cancer is one of the most common malignancies among women. The molecular mechanisms involved in breast carcinogenesis, however, remain to be elucidated. Although somatic mutation of BRCA1 is rare, BRCA1 protein expression is reduced in about 30% of sporadic breast carcinomas (Yoshikawa et al.
Roles of BRCA1 and its interacting proteins
β Scribed by Chu-Xia Deng; Steven G. Brodie
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 178 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0265-9247
No coin nor oath required. For personal study only.
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BRCA1 was the first breast cancer susceptibility gene to be identified and cloned. In individuals from high-risk families, mutations in BRCA1 increase the lifetime risk of developing breast cancer eight to tenfold, compared to the general population. How the BRCA1 protein product normally functions
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