Roles for the TGFβ Superfamily in the Development and Survival of Midbrain Dopaminergic Neurons
✍ Scribed by Hegarty, Shane V.; Sullivan, Aideen M.; O’Keeffe, Gerard W.
- Book ID
- 121557421
- Publisher
- Springer
- Year
- 2014
- Tongue
- English
- Weight
- 452 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0893-7648
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## Abstract Growth/differentiation factor 5 (GDF5) is a novel member of the transforming growth factor‐β (TGF‐β) superfamily of multifunctional cytokines. We show here that GDF5 is expressed in the developing CNS including the mesencephalon and acts as a neurotrophic, survival promoting molecule fo
## Abstract To date, three mammalian TGF‐β isoforms have been identified, each encoded by different genetic loci. Through each is very similar in primary amino acid structure, there are clear differences both in the mature bioactive peptide region and in the latency‐associated peptide, which could