Parkinson's disease is characterized by the progressive degeneration of midbrain dopaminergic neurons. Several studies have examined the effects of the dopaminergic neurotrophins growth/differentiation factor 5 (GDF5) and glial cell line-derived neurotrophic factor (GDNF) on these neurons in vitro.
✦ LIBER ✦
Effects of growth/differentiation factor 5 on the survival and morphology of embryonic rat midbrain dopaminergic neurones in vitro
✍ Scribed by O’Keeffe, Gerard W. ;Dockery, Peter ;Sullivan, Aideen M.
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 315 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0300-4864
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## Abstract Growth/differentiation factor 5 (GDF5) is a novel member of the transforming growth factor‐β (TGF‐β) superfamily of multifunctional cytokines. We show here that GDF5 is expressed in the developing CNS including the mesencephalon and acts as a neurotrophic, survival promoting molecule fo
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