In this groundbreaking book, leading experts detail the cellular and molecular cascades that cause selective degeneration of neuronal populations, and illuminate those genetic and environmental factors that are critical to the facilitation or suppression of the neuropathologic processes. Working fro
✦ LIBER ✦
Role of ubiquitin-mediated proteolysis in the pathogenesis of neurodegenerative disorders
✍ Scribed by Robert Layfield; James R Cavey; James Lowe
- Book ID
- 117798737
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 312 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1872-9649
No coin nor oath required. For personal study only.
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## Abstract To date, nine polyglutamine disorders have been characterised, including Huntington's disease (HD), spinobulbar muscular atrophy (SBMA), dentatorubral‐pallidoluysian atrophy (DRPLA), and spinocerebellar ataxias 1, 2, 3, 6, 7 and 17 (SCAs). Although knockout and transgenic mouse experime