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Role of transport proteins in drug discovery and development: a pharmaceutical perspective

โœ Scribed by Ayrton, A.; Morgan, P.


Book ID
121859892
Publisher
Informa plc
Year
2008
Tongue
English
Weight
219 KB
Volume
38
Category
Article
ISSN
0049-8254

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## Abstract Metabolism by the host organism is one of the most important determinants of the pharmacokinetic profile of a drug. High metabolic lability usually leads to poor bioavailability and high clearance. Formation of active or toxic metabolites will have an impact on the pharmacological and t