Tissue factor (TF) initiates the extrinsic pathway of blood coagulation by acting as a cofactor for Factor VII. Inhibition of the Factor VIIa-TF complex is mediated by the tissue factor pathway inhibitor (TFPI), which is a serine protease inhibitor with three Kunitz-type domains. The localization of
Role of Tissue Factor Pathway Inhibitor in the Regulation of Tissue Factor-Dependent Blood Coagulation
β Scribed by Golino, Paolo ;Ragni, Massimo ;Cimmino, Giovanni ;Forte, Lavinia
- Book ID
- 109106058
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 524 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0897-5957
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π SIMILAR VOLUMES
Tissue factor (TF), a transmembrane glycoprotein, functions as an essential activator of the serine protease factor Vlla. This enzymatic complex is considered to be the principal initiator of in vivo coagulation. Recent studies emphasize the role of the TF/Vlla complex in a number of pathophysiologi
## Abstract ## Objective Clinical and experimental evidence suggests that extravascular fibrin deposition in arthritic joints is prominent and deleterious. The aim of this study was to investigate the contributions of tissue factor (TF) and its inhibitor, TF pathway inhibitor (TFPI), in arthritis.