Role of the α3β1 and α6β4 integrins in tumor invasion
✍ Scribed by Gianluigi Giannelli; Simonetta Astigiano; Salvatore Antonaci; Monica Morini; Ottavia Barbieri; Douglas M. Noonan; Adriana Albini
- Book ID
- 110338272
- Publisher
- Springer
- Year
- 2002
- Tongue
- English
- Weight
- 127 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0262-0898
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## Abstract Metastasizing prostate tumor cells invade along nerves innervating the encapsulated human prostate gland in a process known as perineural invasion. The extacellular matrix laminin class of proteins line the neural route and tumor cells escaping from the gland express the laminin binding
Adhesion to collagens by most cell types is mediated by the integrins a1b1 and a2b1. Both integrin a subunits belong to a group which is characterized by the presence of an I domain in the N-terminal half of the molecule, and this domain has been implicated in the ligand recognition. Since purified
## BACKGROUND. Integrins participate in cell-cell and cell-matrix interactions. In this study we determined whether ␣IIb3 integrin is involved in metastasis of human prostate adenocarcinoma cells. METHODS. Prostate adenocarcinoma PC-3 and DU-145 cell lines express ␣IIb3. Northern blotting, 5Ј-RA