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Role of the tumor suppressor RASSF2 in regulation of MST1 kinase activity

✍ Scribed by Hoogeun Song; Sangphil Oh; Hyun Jung Oh; Dae-Sik Lim

Book ID
116299578
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
434 KB
Volume
391
Category
Article
ISSN
0006-291X

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## Abstract Hypoxia‐inducible factor‐1 (HIF‐1) is a heterodimeric transcription factor that plays a major role in cellular adaptation to hypoxia. The mechanisms regulating HIF‐1 activity occurs at multiple levels __in vivo__. The HIF‐1Ξ± subunit is highly sensible to oxygen and is rapidly degraded b