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Role of the stereochemistry of 3′-fluoro-3′-deoxy analogues of 2-5A in binding to and activation of mouse RNase L

✍ Scribed by Elena N. Kalinichenko; Tatjana L. Podkopaeva; Nicolai E. Poopeiko; Merike Kelve; Mart Saarma; Igor A. Mikhailopulo; Jacquelien E. van den Boogaart; Cornelis Altona


Book ID
104589704
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
932 KB
Volume
114
Category
Article
ISSN
0165-0513

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## Abstract The new amphiphilic dinucleoside phosphate, 2′‐deoxy‐5‐fluorouridylyl‐(3′→5′)‐2′‐deoxy‐5‐fluoro‐__N__^4^‐octadecylcytidine (4) was synthesized on a gram scale, using the phosphotriester method, starting from the cytostatic drug 2′‐deoxy‐5‐fluorouridine (5FdU) and 2′‐deoxy‐5‐fluoro‐__N__