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Role of the proto-oncogene Pokemon in cellular transformation and ARF repression

✍ Scribed by Maeda, Takahiro; Hobbs, Robin M.; Merghoub, Taha; Guernah, Ilhem; Zelent, Arthur; Cordon-Cardo, Carlos; Teruya-Feldstein, Julie; Pandolfi, Pier Paolo

Book ID: 118675830
Publisher: Nature Publishing Group
Year: 2005
Tongue: English
Weight: 606 KB
Volume: 433
Category: Article
ISSN: 0028-0836
DOI: 10.1038/nature03203

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Proto-oncogenes are normal genes which affect normal cell growth and proliferation, but which have the potential to contribute to cancer development if their expression is altered. A variety of events may activate proto-oncogenes and convert them from benign genes to cancer genes. These events inclu