Role of the pentose phosphate pathway in metabolism of Drosophila melanogaster elucidated by mutations affecting glucose 6-phosphate and 6-phosphogluconate dehydrogenases
β Scribed by V.A. Gvozdev; T.I. Gerasimova; G.L. Kogan; O.Yu. Braslavskaya
- Book ID
- 115906339
- Publisher
- Elsevier Science
- Year
- 1976
- Tongue
- English
- Weight
- 367 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0014-5793
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Previous studies examining the regulation of the synthesis of G6PDH and 6PGDH in rat liver and adipose tissue have focused on the induction of these enzymes by different diets and some hormones. In rat liver these enzymatic activities seem to be regulated by a mechanism involving changes in the NADP
The molecular nature of lethal and semilethal mutations in the Pgd locus of D. melanogaster coding for 6-phosphogluconate dehydrogenase (6PGD) was studied. All the 11 mutations affect the structural gene of the Pgd locus: 3 semilethal mutations resulted in altered 6PGD molecules with decreased catal