Role of the newer p53 family proteins in malignancy
โ Scribed by M.S. Irwin; W.G. Kaelin
- Book ID
- 110278198
- Publisher
- Springer
- Year
- 2001
- Tongue
- English
- Weight
- 363 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1360-8185
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
B cell lymphoma gene-2 (Bcl-2) is the prototypic member of a growing family of proteins that play evolutionarily conserved, key regulatory roles in apoptosis. The Bcl-2 family members are characterized by the presence of one or more Bcl-2 homology domains and are comprised of both the prosurvival an
p53-mediated apoptosis involves multiple mechanisms. A number of p53-regulated apoptosis-related genes have been identified. Some of these genes encode proteins that are important in controlling the integrity of mitochondria while the others code for membrane death receptors. p53 may also induce apo