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Role of the Na+,K+-ATPase α2 isoform in the positive inotropic effect of ouabain and marinobufagenin in the rat diaphragm

✍ Scribed by Krivoi, I. I. ;Drabkina, T. M. ;Kravtsova, V. V. ;Vasiliev, A. N. ;Vashchinkina, E. V. ;Prokofiev, A. V. ;Kubasov, I. V.

Book ID
110156795
Publisher
Biophysical Society of Japan
Year
2006
Tongue
English
Weight
158 KB
Volume
51
Category
Article
ISSN
1349-2942

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In this study we have characterized the bumetanide-sensitive K+/Na+/CIcotransport in cultured rat cardiac myocytes. 1) It carries about 10% of the total K + influx. 2) It is sensitive to furosemide (Ki ,,,= 10P'M) and bumetanide