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Role of the mucosal integrin αE(CD103)β7 in tissue-restricted cytotoxicity

✍ Scribed by L. J. C. Smyth; J. A. Kirby; A. C. Cunningham


Book ID
108699613
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
338 KB
Volume
149
Category
Article
ISSN
0009-9104

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## Abstract The I domain of integrin αE was modeled on the crystal structure of that in CD11b and mutated to produce an open (high affinity) or closed (low affinity) conformation. K562 transfectants expressing mutant αE and wild‐type β7 were tested for adhesion to E‐cadherin‐Fc. Downward displaceme