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Adhesion of lymphocytes to bladder cancer cells: the role of the αEβ7integrin

✍ Scribed by Joanne Cresswell; Wai Wong; Matthew J. Henry; Helen Robertson; David E. Neal; John A. Kirby

Book ID
105966564
Publisher
Springer-Verlag
Year
2002
Tongue
English
Weight
234 KB
Volume
51
Category
Article
ISSN
0340-7004

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## Abstract The I domain of integrin αE was modeled on the crystal structure of that in CD11b and mutated to produce an open (high affinity) or closed (low affinity) conformation. K562 transfectants expressing mutant αE and wild‐type β7 were tested for adhesion to E‐cadherin‐Fc. Downward displaceme