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Role of the LRP-RanBP9 pathway in APP processing and Alzheimer's disease susceptibility

✍ Scribed by David E. Kang; Madepalli K. Lakshmana; Eileen Tak; Edward H. Koo; Il-Sang Yoon; Eunice Chen

Book ID
118465522
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
109 KB
Volume
5
Category
Article
ISSN
1552-5260

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In both trisomy 21 and rare cases of triplication of amyloid precursor protein (APP) Alzheimer's disease (AD) pathological changes are believed to be secondary to increased expression of APP. We hypothesized that sporadic AD may also be associated with changes in transcription of APP or its metabol