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Expression of APP pathway mRNAs and proteins in Alzheimer’s disease

✍ Scribed by Matsui, Toshifumi (author);Ingelsson, Martin (author);Fukumoto, Hiroaki (author);Ramasamy, Karunya (author);Kowa, Hisatomo (author);Frosch, Matthew P. (author);Irizarry, Michael C. (author);Hyman, Bradley T. (author)

Book ID
113502843
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
399 KB
Volume
1161
Category
Article
ISSN
0006-8993

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Expression of APP pathway mRNAs and prot
Expression of APP pathway mRNAs and proteins in Alzheimer’s disease
✍ Matsui, Toshifumi (author);Ingelsson, Martin (author);Fukumoto, Hiroaki (author) 📂 Article 📅 2007 🏛 Elsevier Science 🌐 English ⚖ 399 KB

In both trisomy 21 and rare cases of triplication of amyloid precursor protein (APP) Alzheimer's disease (AD) pathological changes are believed to be secondary to increased expression of APP. We hypothesized that sporadic AD may also be associated with changes in transcription of APP or its metabol