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Role of the genetic background of rats in infection by HTLV-I and HTLV-II and in the development of associated diseases

✍ Scribed by Mirdad Kazanji; Fera Ibrahim; Laurence Fiette; Robert Bomford; Guy De Thé

Publisher
John Wiley and Sons
Year
1997
Tongue
French
Weight
217 KB
Volume
73
Category
Article
ISSN
0020-7136

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✦ Synopsis

Three aspects of the rat model of HTLV-I/II infection were investigated. (i) The efficacy of HTLV-I-transformed rat cell lines in infecting different strains of rats: WKY and Lewis HTLV-I-transformed cell lines were injected into adult WKY, Lewis and Brown Norway rats, representing syngeneic and allogeneic combinations. The HTLV-I provirus was not detected in peripheral-blood mononuclear cells (PBMC) from these rats 18 weeks after inoculation, showing that HTLV-Itransformed rat cells are not suitable for virus challenge in vaccination experiments. Rats inoculated with Lewis HTLV-Itransformed cells produced an antibody response to HTLV-I, which was higher in allogeneic (WKY and Brown Norway) than in syngeneic rats. (ii) The susceptibility of rats to HTLV-II infection: After human HTLV-II-producing cells (MO) were injected into adult WKY rats, the HTLV-II provirus was detected in PBMC 12 weeks later. Sequencing of a portion of this provirus confirmed its identity with the HTLV-II from MO cells. (iii) The role of MHC haplotype in susceptibility to neurological disease in rats inoculated as newborns with HTLV-I: The hypothesis that the RT-I k haplotype confers susceptibility was tested by inoculating newborn OKA (RT-I k ), WKY (RT-I l ), Lewis (RT-I l ) and Fischer 344 (RT-I lvl ) rats with human HTLV-I-producing cells (MT-2). Eighteen months later, only the WKY rats showed histological abnormality of the spinal cord, without clinical paralysis. Fischer 344 rats developed cutaneous tumors and OKA rats mammary tumors. The HTLV-I provirus was not detected in these tumors. Int.

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