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Role of HTLV-1 proviral DNA load and clonality in the development of adult T-cell leukemia/lymphoma in asymptomatic carriers

โœ Scribed by Akihiko Okayama; Sherri Stuver; Masao Matsuoka; Junzo Ishizaki; Gen-ichi Tanaka; Yoko Kubuki; Nancy Mueller; Chung-cheng Hsieh; Nobuyoshi Tachibana; Hirohito Tsubouchi

Publisher
John Wiley and Sons
Year
2004
Tongue
French
Weight
430 KB
Volume
110
Category
Article
ISSN
0020-7136

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โœฆ Synopsis

Human T-lymphotropic virus type 1 (HTLV-1) is the causative agent for adult T-cell leukemia/lymphoma (ATL). [1][2][3] Only a small proportion of HTLV-1 carriers eventually develop ATL after a long latency. 4 However, the critical events in the leukemogenic process remain unclear. In general, viral load is an important factor affecting the outcome of virus-associated disease. The HTLV-1 proviral DNA load in the peripheral blood mononuclear cells (PBMCs) of carriers exhibits a wide range of values. 5 Enhanced expression of HTLV-1 Tax, which

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