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Role of the GABA-benzodiazepine-receptor complex in the mechanism of the anxtolytic action of 3-hydroxypyridines — New tranquilizers with a nonbenzodiazepine structure

✍ Scribed by T. A. Voronina; L. D. Smirnov; U. M. Tilekeeva; K. M. Dyumaev


Publisher
Springer US
Year
1986
Tongue
English
Weight
263 KB
Volume
101
Category
Article
ISSN
0007-4888

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Several substituted 2-pyridazinyl benzoxazole derivatives (VII), (VIII) and (IX) are prepared and evaluated for their utility as 5-HT 3 receptor agonists. A detailed structure-activity relationship study is presented. The most promising results are obtained for the derivatives (VIIa), (VIId) and (VI