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Role of the E45K-reduced folate carrier gene mutation in methotrexate resistance in human leukemia cells

โœ Scribed by Gifford, A J; Haber, M; Witt, T L; Whetstine, J R; Taub, J W; Matherly, L H; Norris, M D

Book ID
110055212
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
464 KB
Volume
16
Category
Article
ISSN
0887-6924

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Reduced folate carrier mutations are not
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Folate receptor-โฃ (FR-โฃ) is generally over-expressed in non-mucinous human ovarian carcinomas. The meaning of FR-โฃ over-expression and its role in the 5-methyltetrahydrofolic acid (N 5 -CH 3 -H 4 PteGlu) transport in such tumors is not clear, especially compared with the reduced folate carrier (RFC)