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Role of the Conserved Phenylalanine 181 of NADPH−Cytochrome P450 Oxidoreductase in FMN Binding and Catalytic Activity †

✍ Scribed by Paine, Mark J. I.; Ayivor, Steven; Munro, Andrew; Tsan, Pascale; Lian, Lu-Yun; Roberts, Gordon C. K.; Wolf, C. Roland


Book ID
125981769
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
328 KB
Volume
40
Category
Article
ISSN
0006-2960

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## Abstract The NADPH‐cytochrome P450 oxidoreductase (CYPOR) enzyme is a membrane‐bound protein and contains both FAD and FMN cofactors. The enzyme transfers two electrons, one at a time, from NADPH to cytochrome P450 enzymes to function in the enzymatic reactions. We previously expressed in __Esch