Role of the CD45 (T-200) molecule in anti-CD3-triggered T cell-mediated cytotoxicity
β Scribed by Richard L. Deem; Fergus Shanahan; Adrene Niederlehner; Stephan R. Targan
- Book ID
- 113134053
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 967 KB
- Volume
- 117
- Category
- Article
- ISSN
- 0008-8749
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CD4, CD8 and CD45 regulate the coupling of the T-cell receptor complex (CD3-TCR) to tyrosine kinase activation and phosphorylation of key substrates such as phospholipase C gamma 1. CD4 and CD8 contribute to activation signals through their cytoplasmic association with p56lck. Expression of the zeta
## Abstract The cure of human Hodgkin's tumors heterotransplanted into SCID mice can be achieved by two bispecific monoclonal antibodies (BiβmAb) directed against the tumorβassociated CD30 antigen and CD3 and CD28, respectively, and normal peripheral human blood T cells. We investigated the role of