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Role of the C-terminus and the long cytoplasmic loop in reduced folate carrier expression and function

✍ Scribed by Iraida G. Sharina; Rongbao Zhao; Yanhua Wang; Solomon Babani; I.David Goldman

Book ID
113993052
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
214 KB
Volume
63
Category
Article
ISSN
0006-2952

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Role of folate receptor and reduced fola
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Folate receptor-␣ (FR-␣) is generally over-expressed in non-mucinous human ovarian carcinomas. The meaning of FR-␣ over-expression and its role in the 5-methyltetrahydrofolic acid (N 5 -CH 3 -H 4 PteGlu) transport in such tumors is not clear, especially compared with the reduced folate carrier (RFC)

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## Abstract ## BACKGROUND High‐dose methotrexate (MTX) is an important component of current protocols for the treatment of osteosarcoma. Although MTX uptake proceeds primarily through the reduced folate carrier (RFC) protein and efflux occurs via multidrug resistance protein 1 (MRP1), RFC protein