The key role of heme to trigger the anti
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Anne Robert; FranΓ§oise Benoit-Vical; Bernard Meunier
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Article
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2005
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Elsevier Science
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English
β 479 KB
Artemisinin is an efficient antimalarial drug containing a 1,2,4-trioxane, which is able to alkylate heme both in vitro and in vivo, giving rise to covalent heme-artemisinin coupling products. The low valent iron(II) protoporphyrin-IX, which is the prosthetic group of hemoglobin, induces the homolys