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Role of the Acid Moieties in the Toxic Actions of Pyrrolizidine Alkaloids on Liver and Lung

โœ Scribed by MATTOCKS, A. R.

Book ID
109675580
Publisher
Nature Publishing Group
Year
1970
Tongue
English
Weight
254 KB
Volume
228
Category
Article
ISSN
0028-0836

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๐Ÿ“œ SIMILAR VOLUMES

2184. A new dimension in pyrrolizidine a
2184. A new dimension in pyrrolizidine alkaloid toxicity: Armstrong, Slyvia J. & Zuckerman, A. J. (1970). Production of pyrroles from pyrrolizidine alkaloids by human embryo tissue. Nature, Lond. 228, 569 Mattocks, A. R. (1970). Role of the acid moieties in the toxic actions of pyrrolizidine alkaloids on liver and lung. Nature, Lond. 228, 174. Culvenor, C. D. J., Downing, D. T., Edgar, J. A, & Jago, M. V. (1969). Pyrrolizidine alkaloids as alkylating and antimitotic agents. Ann. N.Y. Acad. Sci. 163, 837
๐Ÿ“‚ Article ๐Ÿ“… 1971 ๐Ÿ› Elsevier Science โš– 143 KB
Role of cellular calcium homeostasis in
Role of cellular calcium homeostasis in toxic liver injury induced by the pyrrolizidine alkaloid senecionine and the alkenaltrans-4-OH-2-hexenal
โœ Griffin, Donna S. ;Segall, H. J. ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 699 KB

The pyrrolizidine alkaloid senecionine has been shown to be hepatotoxic, genotoxic, and cytotoxic. However, the biochemical mechanism by which senecionine produces hepatocellular toxicity remains to be elucidated. The role of calcium homeostasis in toxic liver injury was examined in isolated rat hep