Lesions in the liver and lungs of rats given pyrrole derivatives of pyrrolizidine alkaloids
β Scribed by W. H. Butler; A. R. Mattocks; A. J. M. Barnes
- Publisher
- John Wiley and Sons
- Year
- 1970
- Tongue
- English
- Weight
- 993 KB
- Volume
- 100
- Category
- Article
- ISSN
- 0022-3417
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Pyrrolizidine alkaloids have long been considered to be hepatotoxic in man as well as in grazing animals. To investigate the effect of liver cell division induced by thioacetamide on the hepatic changes induced by these alkaloids, rats were treated concurrently with thioacetamide and th
The pharmacokinetics of acetaminophen was examined in rats after administration of a single dose of 200 mg kg-1 by the intra-arterial, intravenous, portal vein, and oral routes. Levels of acetaminophen and its two major metabolites, acetaminophen-glucuronide and acetaminophen-sulfate, were quantitat
The pyrrolizidine alkaloid senecionine has been shown to be hepatotoxic, genotoxic, and cytotoxic. However, the biochemical mechanism by which senecionine produces hepatocellular toxicity remains to be elucidated. The role of calcium homeostasis in toxic liver injury was examined in isolated rat hep