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Role of T antigen interactions with p53 in tumorigenesis

✍ Scribed by James M Pipas; Arnold J Levine

Book ID
112265014
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
181 KB
Volume
11
Category
Article
ISSN
1044-579X

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The role of SV40 large tumor T-antigen in replication of viral DNA is well established, but it is still unclear how T-antigen triggers cellular replication and cell transformation in non-permissive cells. Here, we used Xenopus egg extracts which reproduce most nuclear events linked to the cell cycle