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Role of sulfhydryl groups in the hydroxylation of benzo[a]pyrene by purified rat and rabbit cytochrome P-448

✍ Scribed by Joseph C. Kawalek; Wayne Levin; Dene Ryan; Anthony Y.H. Lu

Book ID
115703437
Publisher
Elsevier Science
Year
1977
Tongue
English
Weight
879 KB
Volume
183
Category
Article
ISSN
0003-9861

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## Abstract The potent carcinogen benzo[a]pyrene (B[a]P) and its metabolite B[a]P __trans__‐7, 8‐dihydrodiol (7, 8‐diol) require metabolic activation by the microsomal cytochrome P450s (P450s) to exert several adverse biological effects, including binding to DNA, toxicity, mutagenicity, and carcino