Role of Ser-237 in the substrate specificity of the carbapenem-hydrolyzing class A β-lactamase Sme-1
✍ Scribed by Wladimir Sougakoff; Thierry Naas; Patrice Nordmann; Ekkehard Collatz; Vincent Jarlier
- Book ID
- 114150001
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 268 KB
- Volume
- 1433
- Category
- Article
- ISSN
- 0167-4838
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## Abstract The SHV‐type β‐lactamase SHV‐2A is related to SHV‐1 by a Gly‐238‐Ser replacement. Strains carrying SHV‐2A are resistant to the third generation cephems cefotaxime and ceftizoxime, whereas those that carry SHV‐1 are sensitive to these drugs. We present a kinetic analysis of a SHV‐1 and S
Bacterial resistance to -lactam antibiotics, a clinically worrying and recurrent problem, is often due to the production of -lactamases, enzymes that efficiently hydrolyze the amide bond of the -lactam nucleus. Imipenem and other carbapenems escape the activity of most active site serine -lactam