Reactive oxygen metabolites have been implicated in the pathogenesis of toxic, ischaemic and immunologically mediated renal injury. An increase in the cytosolic free Ca2+ concentration ([Ca2+]i) has been proposed as a mechanism of oxidative stress-induced cell injury. We used a fluorescence spectrom
โฆ LIBER โฆ
Role of reactive oxidants in lethal cell injury caused by energy depletion
โ Scribed by Frank F. Sun; Bruce M. Taylor; William E. Fleming
- Book ID
- 113386174
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 150 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0891-5849
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## Abstract Naphthalene is metabolized in the lung and liver to reactive intermediates by cytochrome P450 enzymes. These reactive species deplete glutathione, covalently bind to proteins, and cause necrosis in Clara cells of the lung. The importance of glutathione loss in naphthalene toxicity was i