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On the role of mitochondria in cell injury caused by vanadate-induced Ca2+ overload

โœ Scribed by P. Richelmi; F. Mirabelli; A. Salis; G. Finard; F. Berte; G. Bellomo


Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
1006 KB
Volume
57
Category
Article
ISSN
0300-483X

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The mechanism of the induction of apoptosis by arsenic trioxide (As 2 O 3 ), which was demonstrated recently to be an effective inducer of apoptosis in patients with leukemia, was examined in detail in human leukemia U937 cells. Upon treatment of U937 cells with 50 M of As 2 O 3 , complete inactivat