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Role of Protein Kinase C in Growth Stimulation of Primary Mouse Colonic Epithelial Cells

✍ Scribed by Christina Branting, Rune Toftgård, Inger Porsch Hällström and Joseph Rafter

Book ID
125624566
Publisher
Society for In Vitro Biology
Year
1995
Tongue
English
Weight
537 KB
Volume
31
Category
Article
ISSN
1475-2689

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The human colon cancer cell lines HCT I I 6 (poorly differentiated) and GEO (well differentiated) express the mitogenic peptide transforming growth factor alpha (TGF-a). The secretion of TGF-awas enhanced by phorbol 12-myristate 13-acetate (PMA), indicating the possible role of protein kinase C (PKC