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Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

✍ Scribed by Kapoor, Mohit; Martel-Pelletier, Johanne; Lajeunesse, Daniel; Pelletier, Jean-Pierre; Fahmi, Hassan

Book ID: 115438498
Publisher: Nature Publishing Group
Year: 2010
Tongue: English
Weight: 343 KB
Volume: 7
Category: Article
ISSN: 1759-4790
DOI: 10.1038/nrrheum.2010.196

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## Abstract Studies using mouse axotomised facial motoneuron model show a strong and highly selective entry of CD3+ lymphocytes into the affected nucleus, with a maximum at Day 14, which coincides with the peak of neuronal cell death, microglial phagocytosis, and increased synthesis of interleukin‐