Role of Proinflammatory Cytokines in Acetaminophen Hepatotoxicity
โ Scribed by M.E. Blazka; J.L. Wilmer; S.D. Holladay; R.E. Wilson; M.I. Luster
- Book ID
- 112265896
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 794 KB
- Volume
- 133
- Category
- Article
- ISSN
- 0041-008X
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Acetaminophen is a mild analgesic and antipyretic agent known to cause centrilobular hepatic necrosis at toxic doses. Although this may be due to a direct interaction of reactive acetaminophen metabolites with hepatocyte proteins, recent studies have suggested that cytotoxic mediators produced by pa