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Role of presenilin in γ-secretase cleavage of amyloid precursor protein

✍ Scribed by W Xia


Book ID
114253425
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
70 KB
Volume
35
Category
Article
ISSN
0531-5565

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## Abstract The presenilin/γ‐secretase protease cleaves many type‐I membrane proteins, including the amyloid β‐protein (Aβ) precursor (APP). Previous studies have shown that apoptosis induces alterations in Aβ production in a caspase‐dependent manner. Here, we report that staurosporine (STS)‐induce